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Biomolecules in the Gas Phase / Structure and Solvation |
Michel Mons - Eric Gloaguen |
After structural studies of the simplest model peptide chains, which allowed us to characterize the typical secondary structures of proteins (ANR-blanc "LASIHMODo" project - BLAN-08-0158- for "LASer Studies of Isolated and Hydrated peptides for an improved MODelling of proteins"; 2009-2012), the current work is now focused on more complex model peptides and aims at further characterizing the several interactions taking place within a protein, and concerns more particularly the following issues: i) the influence of hydration on the structural properties, including the flexibility of the peptide backbone; ii) the influence of heteroatomes like sulfur, the interactions of which within proteins are still to poorly documented, iii) the role of aromatic residues in the spontaneous formation of hydrophobic domains. |
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