Laboratoire Francis PERRIN
URA CNRS-CEA 2453
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Primary processes induced in DNA by absorption of UV radiation

 

The characterization of the primary events that are induced by absorption of UV radiation by DNA is important in two respects. On the one hand, it sheds light on the fundamental processes involved in the UV-induced damage to the genetic code. On the other hand, the determination of the factors that govern the DNA optical properties may contribute to the design of DNA-inspired materials for optoelectronics.  

In this context, we study various DNA systems in solution:

 

monomeric chromophores: bases, nucleosides, nucleotides

model helices and natural DNA

G-quadruplexes